733 research outputs found

    Prevention of breast cancer by recapitulation of pregnancy hormone levels

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    At the present time, the only approved method of breast cancer prevention is use of the selective estrogen receptor modulator (SERM) tamoxifen. Many breast cancers are driven to grow by estrogen, and tamoxifen exploits this by blocking estrogen action at the estrogen receptor. A counter-intuitive and controversial approach to breast cancer prevention is administration of estrogen and progestin at an early age to achieve pregnancy levels. This approach is supported by the fact that breast cancer incidence is halved by early (≤ 20 years of age) full-term pregnancy. Moreover, it has been demonstrated in rodent models that mimicking the hormonal milieu can effectively prevent carcinogen-induced mammary cancer. In this issue of Breast Cancer Research Rajkumar and colleagues use the rodent model to further define the timing and type of hormonal therapy that is effective in preventing mammary carcinogenesis. Clearly, application of this approach in humans may be difficult, but the potential benefit is intriguing

    Pregnancy-induced changes in cell-fate in the mammary gland

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    The protective effect of an early full-term pregnancy is a well established phenomenon; in contrast, the molecular and cell-specific mechanisms that govern parity-specific changes in the mammary gland have not been well described. Recent studies signify a dramatic advance in our understanding of this phenomenon, and indicate a 'cell fate' model for parity-related changes that lead to protection against breast cancer

    An evaluation of possible mechanisms for anomalous resistivity in the solar corona

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    A wide variety of transient events in the solar corona seem to require explanations that invoke fast reconnection. Theoretical models explaining fast reconnection often rely on enhanced resistivity. We start with data derived from observed reconnection rates in solar flares and seek to reconcile them with the chaos-induced resistivity model of Numata & Yoshida (2002) and with resistivity arising out of the kinetic Alfv\'en wave (KAW) instability. We find that the resistivities arising from either of these mechanisms, when localized over lengthscales of the order of an ion skin depth, are capable of explaining the observationally mandated Lundquist numbers.Comment: Accepted, Solar Physic

    Extraction and characterization of fibre from musa plant bract

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    191-194An attempt has been made to extract the fibres from banana bracts which have several advantages in terms of environmental friendliness, sustainability and converting the waste into wealth. The banana bract fibres are extracted through mechanical and chemical treatments. The fibre characteristics, such as length, fibre strength, fibre elongation, and moisture regain, has been tested and analyzed. The bract fibre yield percentage varies from 1.02 to 1.84. Most of the bract fibres possess 14 - 24 cm length, which is sufficient to produce textile staple spun yarn. The banana bract fibre has the moisture regain of 8.51-11.63%. The fibre length, tensile strength, fibre elongation and moisture properties of the banana bract fibre show that the bract fibre can be used as raw materials for the production of biodegradable yarn. The 6s Ne rotor staple spun yarns has been successfully produced from bract fibre using miniature lab model rotor spinning machine

    Extraction and characterization of fibre from musa plant bract 

    Get PDF
    An attempt has been made to extract the fibres from banana bracts which have several advantages in terms of environmental friendliness, sustainability and converting the waste into wealth. The banana bract fibres are extracted through mechanical and chemical treatments. The fibre characteristics, such as length, fibre strength, fibre elongation, and moisture regain, has been tested and analyzed. The bract fibre yield percentage varies from 1.02 to 1.84. Most of the bract fibres possess 14 - 24 cm length, which is sufficient to produce textile staple spun yarn. The banana bract fibre has the moisture regain of 8.51-11.63%. The fibre length, tensile strength, fibre elongation and moisture properties of the banana bract fibre show that the bract fibre can be used as raw materials for the production of biodegradable yarn. The 6s Ne rotor staple spun yarns has been successfully produced from bract fibre using miniature lab model rotor spinning machine
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